Updated June 22, 2017 23:51:47

Photo: Emergency service crews at the scene of a truck crash on Tyabb-Tooradin Road in the Mornington Peninsula. (AAP: Andrew Batsch)

A "massive explosion" shook nearby houses after a tanker and a car collided on Victoria's Mornington Peninsula, with at least a hundred firefighters at the scene.

The tanker, carrying flammable material collided with the car at about 8.15pm (AEST) on Thursday, investigators believe.

Tyabb local Bruce Thompson said he heard a series of explosions from his home, which is 500m from the accident site.

"I heard a massive explosion and then five or six smaller explosions after that," he said.

"It really shook the house."

Mr Thompson said there had been smaller incidents on the highway but it was a good road.

It is believed a B-double truck carrying liquid, possibly petrol, was involved in the crash, which caused a fire.

A Country Fire Authority spokeswoman said at least 100 firefighters were working to extinguish the blaze caused by the explosion and they were expected to remain through the night.

Victoria Police spokeswoman Jess Brennan said emergency services were at the scene.

"There was a fire shortly after the crash which has prevented emergency services from getting closer until the area is deemed safe," she said.

Ambulance Victoria said a man with minor injuries was treated at the scene.

He was taken to Frankston Hospital in a stable conditions but paramedics remain at the accident site.

It is unclear if any other injuries have been reported.

AAP

Topics: disasters-and-accidents, accidents, tyabb-3913

First posted June 22, 2017 22:10:24