He'll need it on his first trip to Asia -- he landed in Japan late Wednesday local time -- as tensions flare in the volatile region.
Tillerson will need to convince both that it's in their best interests to remain committed to the United States, and its controversial missile defense system.
However, his diplomatic skills will get their biggest test on the last leg of his trip when he becomes the first Trump Cabinet member to visit China and seeks to tap the country's perceived leverage over the North Korean regime.
Here, CNN's Asia correspondents detail the challenges Tillerson faces on each stop:
Tokyo (CNN) -- Tillerson's most pressing issue in Japan -- like the region as a whole -- is the growing nuclear threat from North Korea.
Tillerson will meet with Abe and his counterpart Foreign Minister Fumio Kishida, with Japan seeking reassurance from the United States that it remains Washington's closest and most trusted ally in the Asia-Pacific.
Though Trump frayed nerves on the campaign trail by calling into question US alliances in the region, the new administration has mostly dialed back that rhetoric.
Tensions between Japan and the US' other big ally in the region, South Korea, could provide a challenge for Tillerson as he seeks to rein in North Korea.
With deft, old-fashioned diplomacy, Tillerson has to find a way to encourage Japan and South Korea to resolve their issues so all three countries can focus on the growing threat Pyongyang poses to regional and global security.
From CNN's Will Ripley
Seoul (CNN) -- The main challenge for South Korean officials when Tillerson arrives is to convince him it's business as usual, when it's anything but.
But those holding the fort will work hard to get the assurances they want from the top US diplomat.
Tillerson will meet acting President Hwang Kyo-ahn for the first time and Foreign Minister Yun Byung-se, whom he met in February at the G20 foreign ministers' meeting in Bonn, Germany.
Tillerson also arrives at a time when Seoul claims Beijing is punishing it economically for agreeing to install THAAD, the US missile defense system that Washington says is needed to counter the North Korean missile threat.
With Park now out of the picture, he'll also be seeking assurances that South Korea's new leader honors the agreement. Snap elections will be held on May 9.
From CNN's Paula Hancocks
It would be the first meeting between the two men, in what many argue is the most important bilateral relationship in the world.
There is no shortage of items that should be discussed.
High on the list will be the ongoing crisis in North Korea. Since the beginning of 2016, two nuclear tests and dozens of ballistic missile tests have ratcheted up tensions on the peninsula. The Trump administration wants China to do more to curb the threat.
Despite fiery rhetoric on the campaign trail, President Trump and his administration have taken a relatively hands off approach to China so far.
The Secretary of State's visit to China has the potential to set the tone for the upcoming Xi-Trump meeting.
It could be the opening salvo in the Trump's administration's previous promises to "get tough" on China, or it could be a continuation of the relatively calm period we've seen since inauguration day.
From CNN's Matt Rivers