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The deadline for Biden's withdrawal is significant -- September 11, 2021, is 20 years after the 9/11 terror attacks in New York, Washington, DC, and Pennsylvania that led the US to target Afghanistan in the first place.
Those two decades have seen more than 2,300 US military lives lost, tens of thousands of US wounded, countless Afghan casualties and more than $2 trillion in taxpayer money spent.
After all that, the last US troops to depart -- some of them surely born after the 9/11 attacks -- will leave parts of Afghanistan under the control of the same oppressive Taliban leaders who were there in 2001.
Here is a brief attempt to bring those 20 years of war into perspective.
Where did the Taliban come from?
The Soviets occupied Afghanistan during the 1980s and ultimately withdrew after resistance from fighters, collectively known as mujahadeen. Among them was Osama bin Laden. The US funneled arms and help to these anti-Soviet forces. But in the post-Soviet power vacuum, the Taliban was formed under the leadership of Mullah Mohammed Omar, who wanted to create an Islamic society, expel foreign influences like TV and music from the country and impose a repressive version of Islamic law that is particularly harsh on women. By 2001, they controlled nearly all of the country.
Why did the US invade Afghanistan in the first place?
It was al Qaeda, the international terror network, not Afghanistan's Taliban -- a regional Islamic political and military force -- that attacked the US on 9/11.
But the masterminds of the attack, including Osama bin Laden, had been operating out of under the cover of the Taliban, which refused to give up bin Laden in the wake of the attack.
Was there bipartisan support for invading Afghanistan in 2001?
What did the President George W. Bush say when the US invaded Afghanistan?
The invasion, led by US forces with help from NATO allies, was framed specifically as a step in a war on terrorism.
"These carefully targeted actions are designed to disrupt the use of Afghanistan as a terrorist base of operations and to attack the military capability of the Taliban regime," he said, pointing out the name of the operation was "Enduring Freedom," although in hindsight it might be enduring war.
"Since September 11, an entire generation of young Americans has gained new understanding of the value of freedom and its cost and duty and its sacrifice," he later said.
Since then, a new generation of Americans has been born and come of age while the war that started that day carried on, often in the background with little focus from most of the public.
How many troops have been in Afghanistan in the past 20 years?
How many US troops died each year in Afghanistan?
The most deadly years were after Obama's surge of troops in 2009. The most deadly year for both the US and its NATO allies was 2010. There have been much fewer US deaths since major US and NATO combat operations ended in 2014.
When did this transform from an effort to target al Qaeda?
By late 2001, bin Laden had moved through parts of Afghanistan and had crossed into Pakistan, where he would stay in hiding for nearly a decade until Navy SEALs killed him there in May 2011.
What's it like in Taliban-controlled Afghanistan today?
CNN's Nick Paton Walsh visited Taliban-controlled areas of Afghanistan that were the scene of US and British casualties a decade ago. He and his CNN team found women unable to go outside.
Paton Walsh writes: While Kabul and the center of most main cities remain mostly under government control, vast swathes of rural Afghanistan are ruled by the fractious and varied units of the Taliban. For more than five years now in Musa Qala, they have imposed their rules despite still being in regular conflict with Afghan security forces further south in Helmand province.
"At the end of the day the Taliban have the power," said one resident. "It is not really possible to go against their will."
What exactly is the US trying to accomplish in Afghanistan?
The stated goal of the US involvement is not to liberate women repressed by the Taliban or to end that regime. In fact, the US has been involved in peace talks between the Taliban and the Afghan government for years.
The simplest explanation of the US goal in Afghanistan is to keep it from again becoming a hotbed for terror groups like al Qaeda. When the US left Iraq, for instance, the power vaccum helped lead to the rise of ISIS there.
But what the US has been trying to accomplish in Afghanistan, and the strategy to do it, has changed with each president.
In unvarnished interviews they never thought would become public, American military leaders told government viewers the US was unprepared for Afghanistan and that the American people did not know the "magnitude of dysfunction" in carrying out the war.
Will any US troops be left in Afghanistan after September 11, 2021?
Very few US forces will be there and they will be focused on helping US diplomats. An exact number is unclear. It's not exactly clear, for instance, what role, if any, US special operations troops would play in Afghanistan.
What if conditions in Afghanistan worsen between now and September?
Biden's decision is said to be final and not "conditions-based." This is happening.
What is the reaction to Biden's decision?
There is bipartisan opposition.
"Apparently, we're to help our adversaries ring in the anniversary of the 9/11 attacks by gift-wrapping the country and handing it right back to them," said Senate Minority Leader Mitch McConnell on the Senate floor Wednesday.
Sen. Jeanne Shaheen, a Democrat of New Hampshire, tweeted when word of Biden's plans began circulating: "It undermines our commitment to the Afghan people, particularly Afghan women."
Who supports Biden's decision?
There is support, particularly from progressives and Democrats.
"Year after year, military leaders told Congress and the American people that we were finally turning the corner in Afghanistan, but ultimately we were only turning in a vicious circle," said Massachusetts Sen. Elizabeth Warren in a statement.
It's also in line with Trump's aim of withdrawing from Afghanistan, although the former President has not weighed in.
What will happen after the US and NATO forces leave?
While the US will continue to try to broker a peace agreement between the Afghan government and the Taliban, September may now be the de facto deadline for those talks. Biden is overruling military commanders who worry the Taliban will overrun the Afghan government once American firepower is gone. A US intelligence community assessment released Tuesday shares those concerns.
Why is Biden bent on removing the remaining 2,500 US troops?
Biden said in his speech Wednesday that no amount of US forces on the ground can deter the Taliban or end the war.
The US will still use diplomatic and monetary leverage. What's not at all clear is if those tools will get results where two decades of American military might have not.