Amid the chaos, Michael Neser has said he was unaware he'd taken the ninth hat-trick in BBL history.

It spanned two overs as the Brisbane Heat paceman destroyed the Melbourne Renegades' top order on Wednesday night, reducing them to 4-9 in their run chase.

"S***, that's funny," Neser told reporters post-match when they informed him of the rare feat.

"I didn't realise I took a wicket on that final ball of that over before. It's kind of cool — first hat-trick I've ever taken.

"To be honest, a lot was going on. The wicket was doing a lot, the ball was swinging, so I was really just focused on bowling a good length."

Squeezed out of Australia's Test side, Neser responded in spectacular fashion with four wickets in his first eight deliveries on his return to BBL duty.

The Heat had posted a modest 8-137, batting first, before Neser gave them momentum with the ball.

The 32-year-old snared Sam Harper's wicket with the first delivery of the Renegades' innings and dismissed Jake Fraser-McGurk with the last ball of the same over.

Nic Maddinson was Neser's next victim at the start of the third over and the hat-trick was complete when Jon Wells left one that cannoned into the stumps.

Neser was not far away from the BBL's second double hat-trick when an inswinger went through Andre Russell's gate, narrowly missing off-stump.

The close shave didn't faze Russell, who soon smacked Neser onto the Kardinia Park roof.

It was one of three sixes the West Indies power hitter blasted off Neser, who still finished with career-best T20 figures of 4-32.

"He took me on when the ball was going and it worked in his favour," Neser said.

"I felt like any of those balls could've gone up.