A woman has died following a two-car crash in Adelaide's north-eastern suburbs last night, the third fatality on South Australian roads since Friday evening.

Police and emergency services were called to North East Road at Windsor Gardens just before 10pm on Saturday after reports a Ford Mustang and a Holden station wagon had collided.

Police said a 40-year-old Windsor Gardens woman, who was driving the station wagon, died at the scene.

Police said they arrested the driver of the Mustang, a 22-year-old Ottoway man, and charged him with causing death by dangerous driving.

He was not injured in the crash, according to police, and will appear in court on May 31.

The Windsor Gardens woman's death was the third fatality on South Australian roads this weekend.

A 51-year-old Glenelg woman died yesterday and five others were seriously injured after a two-car crash at Hackham.

SA Police Assistant Commissioner Ian Parrott said one car with two 17-year-olds inside had T-boned another that was exiting onto a main road.

Assistant Commissioner Parrott said investigations were ongoing in the Hackham and Windsor Gardens crashes, including whether speed was a contributing factor in each.

He implored people to take care on the road, particularly young drivers.

Tributes for motorcyclist killed in Barossa

Danny Westhoff, the father of former Port Adelaide Football Club players Justin and Matthew Westhoff, died in a motorcycle crash at Vine Vale in the Barossa on Friday evening.

Assistant Commissioner Parrott said Mr Westhoff's motorcycle left the road and hit a tree at around 5:30pm.

In a statement on Sunday, Port Adelaide chief executive Matthew Richardson said the club was devastated.

"The club sends its heartfelt condolences to Robyn, sons Leigh, Justin and Matthew and extended family," he said.

"Our thoughts are also with the Tanunda Football Club at this time. Danny contributed so much to their club and community."

Assistant Commissioner Parrott said it had been a "horror weekend on South Australian roads".

"This continues an absolutely horror trend on South Australian roads so far this year, with 35 lives lost now in just two-and-a-half months," he said.

"That is a devastating figure in terms of road safety outcomes, but it is incredibly devastating for the families who have lost loved ones on our roads so far this year."

Last month, police urged for care to be taken on SA roads after revealing the state had recorded its second-worst road toll for the start of the year in a decade.

Today, Assistant Commissioner Parrott said police were "frustrated and disappointed" with the road toll.

"The road toll this year is insane, it's absolutely insane," he said.

"And I don't understand why people aren't getting the message."