A lucky ticket-holder has won the entire $150 million Powerball jackpot, becoming Australia's biggest individual lottery winner.

Thursday night's winning entry was bought in Adelaide, South Australia, but the identity of the new multi-millionaire remains unknown as it was not registered to a player card or online account, according to operator The Lott.

The winning numbers were 18, 29, 34, 8, 4, 28 and 6, with a Powerball of 11.

The Lott spokesperson, Khat Intrachai, said she was eagerly waiting for the lucky winner to make contact and claim their prize.

"Someone has become Australia's biggest individual lottery winner and possibly doesn't know it yet," she said.

The largest Powerball prize in Australia's history worth $200 million was claimed by two people in February.

Lottery officials are urging all South Australian residents or visitors who purchased an entry in Thursday night's draw to check their tickets. 

The Lott said lottery winners in South Australia have 12 months to claim their prize, before a process to claim the prize directly from the state government kicks in.

In addition to the $150 million division one winner, there were 4,433,211 winners across divisions two to nine in Thursday's game draw who collectively took home more than $89.3 million.

Mathematician and author, Adam Spencer, said the odds of winning the Powerball draw were one in 134 million.

That means a person has a greater chance of being hit by lightning than winning the division one prize. 

"First of all, you have to get seven correct out of 35," Mr Spencer said.

"That is a one in 6.8 million chance. If you get through that hoop, you then have a one in 20 chance of getting the final ball.

"The total odds are one in 134 million."