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Four people including a police officer have been injured following a car crash and suspected stabbing in Engadine in Sydney's south.
Police said multiple calls were made to triple-0 after a two-car crash at the intersection of Princes Highway and Old Bush Road about 9am.
Terrified witnesses have described a man in a bloodstained shirt banging on their car windows.
One witness who did not want to be identified told the ABC he saw the man get out of the car yelling "I'm going to kill you".
"When the cops came he ran down the street screaming. They shot the taser at him right on the footpath here but it didn't even seem to touch the sides, he just kept bolting," he said.
"He was off his rocker."
Officers arrived and found a man who appeared to have been stabbed allegedly running from the scene.
Police used a taser while arresting the man.
A male police officer suffered a wound to his left wrist during the arrest, police said.
The Princes Highway has been closed in both directions at the intersection of Old Bush Road. (ABC News)
A woman, who police believe was a passenger in one of the vehicles involved in the crash, was found suffering multiple injuries.
The ABC understands she was also stabbed.
Mobile phone footage obtained by the ABC shows the man running from the scene with police in pursuit.
In another video he is pinned to the ground under arrest.
One woman told the ABC her boyfriend had rushed to the scene of the crash with a first aid kit and been threatened by the man.
NSW Police Minister Yasmin Catley said an investigation was underway.
"There is no threat to the community, I just want the community to know that there is no threat whatsoever," she said.
A fourth person was also injured.
Ambulance crews are also at the scene.
The Princes Highway is closed in both directions near Old Bush Road.