A prominent Brisbane restaurant owner, whose brother was bludgeoned to death, has been arrested on drug charges.

Police raided Toowong Italian restaurant Mariosarti on Friday and arrested its owner, Daniel Milos.

Queensland police officers, working with the Australian Criminal Intelligence Commission, also raided 10 other addresses across the Gold Coast and Brisbane, including a Fig Tree Pocket home.

Police said five people in total had been arrested on 33 drug-related charges but did not rule out further charges.

Drug and Serious Crime Group Detective Superintendent Jon Wacker estimated the street value of cocaine seized to be between $750,000 and $1 million. 

He described the operation as a "sophisticated network", saying investigations were ongoing, but added police had targeted a "prominent business person".

"If you wish to distribute dangerous drugs in our area, we will target you, no matter who you are," he said.

Mr Milos' chef brother Daniel, with whom he owned the restaurant, was bludgeoned to death in 2014.

James Thomas Howell was acquitted in February of the chef's murder.

More to come ...