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Skaggs, 27, was found unresponsive Monday afternoon at a Hilton hotel in Southlake, a Dallas-Fort Worth suburb, police said in a statement.
He was pronounced dead at the scene. foul play is not believed to be a factor at this point, and a police spokesman said suicide "is not suspected," according to the Los Angeles Times.
"Tyler has, and always will be, an important part of the Angels Family," the Angels tweeted.
"The Texas Rangers organization wants to express its deepest sympathies to the family of Tyler Skaggs and to the entire Angels organization on this shocking loss," the statement said.
The rest of the series with the Angels will continue as scheduled starting Tuesday, Texas Rangers General Manager Jon Daniels told television station KDFW. But that could change, he said.
Skaggs attended Santa Monica High School in California. The Angels drafted him in 2009, according to his biography. He made his Major League Baseball debut on August 22, 2012, and pitched for the Arizona Diamondbacks for the 2012 and 2013 seasons.
"We are heartbroken with this tragic news. Tyler began his MLB career as a Diamondback and he will always be remembered here as a great teammate and wonderful young man," Derrick Hall, Diamondbacks president and CEO, said in a statement.
He had a 7-7 record this year. He was 28-38 for his MLB career, with a 4.41 ERA, according to his bio.
"I am deeply saddened by today's tragedy in Texas," Major League Baseball Commissioner Rob Manfred said in a statement. "All of us at Major League Baseball extend our deepest condolences to Tyler's wife Carli, their family, their friends and all of his Angels' teammates and colleagues."
A new marriage
Skaggs was married at the end of 2018, according to both his and his wife's Instagram accounts. Photos show them kissing and embracing on their wedding day.
"Howdy y'all," Skaggs' post said. "#TexasRoadtrip"
'We love you, 45'
"There were a lot of pretty emotional guys in our clubhouse. Some guys knew him. Guys were physically shaken," Rangers manager Chris Woodward said, the Times reported. "This isn't something we deal with on a daily basis."
In Anaheim, a banner honoring Skaggs was hoisted outside Angel Stadium. Mourners left flowers and memorabilia in front of the stadium. "RIP 45," was written on an Angels hat.
Jonathan Pickens, an Angels fan from Orange County, posted a picture of the memorial for Skaggs on social media. Pickens told CNN he heard the news of Skaggs' death and "felt like we had to get up and go to be there to pay respect."
CNN's David Close, Nicole Williams, Amanda Jackson, Dave Alsup and Kevin Dotson contributed to this report.