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Roger Federer's first professional title came in 2001, when he was 19 and beat Julien Boutter in three sets on an indoor hard court in Milan.
After 102 more crowns, Federer has announced his retirement at age 41.
But he is best known for his 20 championships at grand slam tournaments: eight at Wimbledon, six at the Australian Open, five at the US Open and one at the French Open.
Here's a look at 10 of Federer's most memorable major finals.
The breakthrough at Wimbledon 2003
Federer won the 1998 junior title at the All England Club, and another sign of what was to come arrived when he ended seven-time Wimbledon champion Pete Sampras's 31-match winning streak in the fourth round there in 2001.
But Federer did not make it past the quarterfinals at any major tournament until two years later at Wimbledon, when he earned his first grand slam trophy at age 21 with a 7-6 (7/5), 6-2, 7-6 (7/3) victory over Australian Mark Philippoussis.
"There was pressure from all sides, also from myself," Federer said that day, after sobbing on court when the match ended.
Opening a New York account in 2004
Federer talked about the noise and all of the goings-on in New York, wondering aloud how he would deal with the conditions and distractions there.
He won it the fifth time he entered, dismantling another Aussie, Lleyton Hewitt, 6-0, 7-6 (3), 6-0. It was the first time there were two bagels dished out in the event's championship match since 1884.
"I'm grateful every tournament, every grand slam I win. You never know which is your last," Federer said.
That would be the first of five triumphs in a row at Flushing Meadows, during which he beat a string of opponents from multiple generations — all major champions and world number ones at some point — in the finals: Andre Agassi, Andy Roddick, Novak Djokovic and Andy Murray.
Rafa's Roland Garros arrival and the birth of the Fedal rivalry
Federer's first grand slam match-up against Rafael Nadal was in the semifinals of the 2005 French Open, which Nadal won en route to his first major trophy at age 19.
Their first grand slam final came a year later in Paris, when Federer was 24 years old and 7-0 in major deciders for his career (the best start for a man since the 1880s).
He also was riding a 27-match unbeaten streak at majors overall after winning Wimbledon, the US Open and Australian Open in a stunning run of form.
The Swiss and the Spaniard had met six times previously, but the 2006 final marked the beginning of what would become an enduring rivalry.
Nadal won 1-6, 6-1, 6-4, 7-6 (7/4) using his high-bouncing, top-spinning lefty forehand to create big problems on Federer's one-handed backhand, something that would be a feature of their 40 matches over the next 13 years.
The greatest Wimbledon final
After losing to Nadal in three straight French Open finals (2006-08) and beating him in two consecutive Wimbledon finals (2006-07), Federer carried winning streaks of 40 matches at the All England Club and 65 on grass courts into their latest meeting.
In what many consider the greatest tennis match in the sport's long history, Nadal ended Federer's bid for a sixth championship in a row at Wimbledon by edging him 6-4, 6-4, 6-7 (5/7), 6-7 (8/10), 9-7 as darkness descended after 9pm in a four-hour, 48-minute test of will as much as skill.
"Probably my hardest loss, by far," Federer said.
The first French in 2009
Federer became the sixth man with a career Grand Slam — at least one trophy at all four majors — and tied Sampras's then-men's record of 14 majors by beating Robin Soderling, who had kindly taken out Nadal, in Paris.
The 6-1, 7-6 (7/1), 6-4 win was one of Federer's five appearances in the title match at Roland Garros, the only one against someone other than Nadal, and therefore his only win.
"I don't know if we'll ever know who was the greatest of all time, but I'm definitely happy to be right up there," Federer said.
The new record at Wimbledon 2009
Federer broke Sampras's men's mark for most major trophies with his 15th by scraping past familiar foil Roddick 5-7, 7-6 (8/6), 7-6 (7/5), 3-6, 16-14.
A shanked backhand volley that would have seen a resurgent Roddick go up two sets to love haunted the American in another classic Wimbledon decider.
Federer broke the big-serving Roddick for the only time in the 77th and last game of a match that lasted 4 hours and 16 minutes — the fifth set alone was 90 minutes long.
Afterward, Federer pulled on a specially tailored white jacket with a gold "15" stitched on the back.
"Now he's an icon," Sampras said.
The return in Melbourne
Federer took the last half of 2016 off after surgery on his left knee, and proved rumours of his death were greatly exaggerated by returning with a remodelled game to claim his first grand slam title since 2012.
Making matters better for the Swiss, he beat rival Nadal 6-4, 3-6, 6-1, 3-6, 6-3, even after going down a break in the fifth set, to grab his 18th major.
Federer entered the day 2-6 against Nadal in major finals and said after the match: "This one means a lot to me because he's caused me problems over the years."
Number eight at Wimbledon 2017
Federer, less than a month before turning 36, won his men's-record eighth Wimbledon trophy, needing just 101 minutes to dismiss 2014 US Open champion Marin Čilić 6-3, 6-1, 6-4.
"Wimbledon was always my favourite tournament. Will always be my favourite tournament," said Federer, the oldest male champion there in the Open era, which began in 1968.
The last hurrah at the 2018 Australian Open
Federer beat Čilić again for his 20th slam overall, although this one at Melbourne Park was much tougher than the last: 6-2, 6-7 (5/7), 6-3, 3-6, 6-1.
"The fairytale continues," he said.
Djokovic denies another Wimbledon crown
Federer came as close as possible to earning title number nine at Wimbledon and his 21st from all slams, but lost to Djokovic 7-6 (7/5), 1-6, 7-6 (7/4), 4-6, 13-12 (7/3) in the first fifth-set tiebreaker in a final at the All England Club.
Federer held two championship points and finished with more total points, more winners, more aces and more breaks of serve but could not overcome the defensive genius of Djokovic.
"I don't want to be depressed about actually an amazing tennis match," Federer said.
AP