Former Jetstar pilot Greg Lynn has told the Supreme Court he is not guilty of murdering two campers in Victoria's High Country, as his highly anticipated trial gets under way.

Mr Lynn, who was dressed in a dark-coloured suit, stood in front of dozens of potential jurors and formally pleaded "not guilty" to murdering Russell Hill and Carol Clay.

Mr Hill, 74, and Ms Clay, 73, were reported missing in March 2020 after going on a camping trip in the Wonnangatta Valley, about a five-hour drive east of Melbourne.

Justice Michael Croucher told a panel of potential jurors on Thursday that Mr Lynn worked as a Jetstar captain and was camping in the same area as the pair around March 20, 2020.

The campers' disappearance sparked a major police search and investigation.

Mr Lynn, now 57, was arrested and charged by police in November 2021.

The court was told about 100 witnesses could be called to give evidence in the trial, including Mr Lynn's wife Melanie, family members of the deceased, scientists, fellow campers and police.

On Thursday, 14 jurors were selected from a large pool of people called up for jury duty. Two jurors will eventually be balloted off at the end of the trial, leaving 12 to deliver verdicts.

The prosecution team is led by Daniel Porceddu, while barrister Dermot Dann KC is spearheading Mr Lynn's defence.

Justice Croucher said the case had "received a lot of publicity" since 2020, and said potential jurors should recuse themselves if they had been following the story closely or felt they could not be impartial.

"It's vital that every member of the jury be completely open-minded about the case that's about to be heard, and not favour one side over another," he said.